NIP-142 | Kv1.5 inhibitor | Probechem Biochemicals

Chemical Structure : NIP-142

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NIP-142 (NIP142)

货号: PC-20298Not For Human Use, Lab Use Only.

NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM.

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生物&药学活性

NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM.
NIP-142 inhibits the hKv1.5 current in a concentration-dependent and voltage-independent manner.
NIP-142 has inhibitory effects on the hKv 1.5 current through interaction with both open and closed states of the channel.
NIP-142 (10 and 100 microM) concentration-dependently prolonged the refractory period and action potential duration in the atrium but not in the ventricle.
NIP-142 completely reversed the carbachol-induced shortening of atrial action potential duration.

物理化学性质&存储条件

分子量	441.48
分子式	C23H27N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-N-[(3R,4S)-4-(Cyclopropylamino)-3,4-dihydro-3-hydroxy-2,2-dimethyl-7-nitro-2H-1-benzopyran-6-yl]-4-methoxybenzeneacetamide

参考文献

1. Matsuda T, et al. Life Sci. 2001 Mar 16;68(17):2017-24.

2. Matsuda T, et al. J Pharmacol Sci. 2005 May;98(1):33-40.

NIP-142 (NIP142)

生物&药学活性

物理化学性质&存储条件

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NIP-142 (NIP142)

生物&药学活性

物理化学性质&存储条件

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