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首页-小分子抑制剂&激动剂-Others-Other Targets-NIO-1
NIO-1

Chemical Structure : NIO-1

CAS No.: 2691184-09-3

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NIO-1 (Novel inhibitor of OCT1)

货号: PC-72028Not For Human Use, Lab Use Only.

NIO-1 (Novel inhibitor of OCT1) is a novel small molecule inhibitor of Octamer transcription factor OCT1, inhibits OCT1 activation with IC50 of 0.11 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NIO-1 (Novel inhibitor of OCT1) is a novel small molecule inhibitor of Octamer transcription factor OCT1, inhibits OCT1 activation with IC50 of 0.11 uM.
    NIO-1 repressed OCT1 activation by repressing recruitment of OCT1 to the binding sites of the promoter region of its downstream genes.
    NIO-1 inhibited recruitment of OCT1 to the promoter region of its downstream genes containing OCT binding sites.
    NIO-1 enhanced the sensitivity of ESCC cells to chemotherapeutic agents.

    物理化学性质&存储条件

    分子量 365.389
    分子式 C20H19N3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-acetyl-2-methoxyphenyl)-2-(4-methyl-1-oxophthalazin-2(1H)-yl)acetamide

    参考文献

    1. Xiao-Zheng Zou, et al. Eur J Pharmacol. 2021 Sep 15;907:174222.

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