NIK SMI1

Chemical Structure : NIK SMI1

CAS No.: 1660114-31-7

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货号: PC-62514Not For Human Use, Lab Use Only.

NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM.

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5 mg	￥2780	In stock
10 mg	￥4580	In stock
25 mg	￥7280	In stock
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100 mg		Get quote

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生物&药学活性

NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM.
NIK SMI1 only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM.
NIK SMI1 potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling.
NIK SMI1 inhibits BAFF and CD40 signaling, suppresses immune responses in vivo.
NIK SMI1 suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice.

物理化学性质&存储条件

分子量	365.389
分子式	C20H19N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-(3-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide

参考文献

1. Brightbill HD, et al. Nat Commun. 2018 Jan 12;9(1):179.

NIK SMI1

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物理化学性质&存储条件

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NIK SMI1

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