NIH-12848 |CAS:959551-10-1 Probechem Biochemicals

Chemical Structure : NIH-12848

CAS No.: 959551-10-1

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NIH-12848 (NIH12848;NIH 12848)

货号: PC-42382Not For Human Use, Lab Use Only.

NIH-12848 is a potent and selective PI5P4Kγ inhibitor with IC50 of 1 uM, shows no significant inhibitory activity for PI5P4Kα and PI5P4Kβ (>100 uM).

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10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

NIH-12848 is a potent and selective PI5P4Kγ inhibitor with IC50 of 1 uM, shows no significant inhibitory activity for PI5P4Kα and PI5P4Kβ (>100 uM).
NIH-12848 inhibits the translocation of Na⁺/K⁺-ATPase to the plasma membrane in mpkCCD cells.
NIH-12848 is a potentially powerful tool for exploring the cell physiology of PI5P4Ks.

物理化学性质&存储条件

分子量	385.4054696
分子式	C20H14F3N3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-

参考文献

1. Clarke JH, et al. Biochem J. 2015 Mar 1;466(2):359-67.

2. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.

NIH-12848 (NIH12848;NIH 12848)

生物&药学活性

物理化学性质&存储条件

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NIH-12848 (NIH12848;NIH 12848)

生物&药学活性

物理化学性质&存储条件

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