NIBR3049 (TCS 21311) | JAK3 inhibitor, PKC inhibitor | Probechem Biochemicals

Chemical Structure : NIBR3049

CAS No.: 1260181-14-3

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NIBR3049 (TCS 21311, NIBR-3049, TCS21311)

货号: PC-62972Not For Human Use, Lab Use Only.

NIBR3049 (TCS 21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NIBR3049 (TCS 21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.

物理化学性质&存储条件

分子量	526.51
分子式	C27H25F3N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

参考文献

1. Thoma G, et al. J Med Chem. 2011 Jan 13;54(1):284-8.

NIBR3049 (TCS 21311, NIBR-3049, TCS21311)

生物&药学活性

物理化学性质&存储条件

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NIBR3049 (TCS 21311, NIBR-3049, TCS21311)

生物&药学活性

物理化学性质&存储条件

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