NIBR-LTSi | Lats kinases inhibitor | Probechem Biochemicals

Chemical Structure : NIBR-LTSi

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NIBR-LTSi (LATS kinase inhibitor)

货号: PC-22068Not For Human Use, Lab Use Only.

NIBR-LTSi is a potent, highly selective and orally active LATS kinase inhibitor with IC50 of 1.4 nM in biochemical CALIPER assay, potently reduces pYAP levels with IC50 of 2.16 uM in JHH5 cells.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

NIBR-LTSi is a potent, highly selective and orally active LATS kinase inhibitor with IC50 of 1.4 nM in biochemical CALIPER assay, potently reduces pYAP levels with IC50 of 2.16 uM in JHH5 cells.
NIBR-LTSi robustly reduces YAP phosphorylation and increases proliferation in wild-type (WT) HEK293A cells but not in HEK293A cells with LATS kinase deletion.
NIBR-LTSi (10 uM) promotes primary keratinocyte expansion and blocks differentiation in human 3D skin model.
NIBR-LTSi promotes liver organoid formation (EC50=0.35 uM) and hepatocyte proliferation, NIBR-LTSi-induced YAP signaling enables BEC organoid formation and growth in the absence of WNT/β-catenin-inducing agents.
NIBR-LTSi promotes YAP/TAZ-dependent hepatocyte proliferation and accelerates liver regrowth in AAV8-induced YAP/TAZΔHEP.
NIBR-LTSi induces proliferation of kidney TECs, promotes ISC expansion and blocks their differentiation in organoids and in vivo, accelerates liver regeneration, following partial and extended hepatectomy.

物理化学性质&存储条件

分子量	308.39
分子式	C18H20N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(4-(piperidin-3-yloxy)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-amine

参考文献

1. Namoto K, et al. Cell Stem Cell. 2024 Apr 4;31(4):554-569.e17.

NIBR-LTSi (LATS kinase inhibitor)

生物&药学活性

物理化学性质&存储条件

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NIBR-LTSi (LATS kinase inhibitor)

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物理化学性质&存储条件

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