NI-57 |CAS:1883548-89-7 Probechem Biochemicals

Chemical Structure : NI-57

CAS No.: 1883548-89-7

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NI-57 (BRPF inhibitor NI57)

货号: PC-62286Not For Human Use, Lab Use Only.

NI-57 is a potent inhibitor of the bromodomain of the BRPFs and binds to BRPF1B, BRPF2 and BRPF3 and with KD of 31 nM,108 nM and 408 nM (ITC), respectively.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

NI-57 is a potent inhibitor of the bromodomain of the BRPFs and binds to BRPF1B, BRPF2 and BRPF3 and with KD of 31 nM,108 nM and 408 nM (ITC), respectively.
NI-57 shows highly selectivity against other non-Class IV bromodomains, including the BETs, as measured by both biophysical and biochemical methods.
NI-57 displays 32-fold selectivity over the closest off-target BRD9.
NI-57 shows accelerated FRAP recovery at 1 uM in the BRPF2 FRAP assay preventing binding of full-length BRPF2 to chromatin.

物理化学性质&存储条件

分子量	383.422
分子式	C19H17N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide

参考文献

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

2. Igoe N, et al. J Med Chem. 2017 Aug 10. doi: 10.1021/acs.jmedchem.7b00611.

NI-57 (BRPF inhibitor NI57)

生物&药学活性

物理化学性质&存储条件

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NI-57 (BRPF inhibitor NI57)

生物&药学活性

物理化学性质&存储条件

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