NI-42 |CAS:1884640-99-6 Probechem Biochemicals

Chemical Structure : NI-42

CAS No.: 1884640-99-6

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NI-42 (NI42;NI 42;BRPF1 inhibitor NI-42)

货号: PC-61007Not For Human Use, Lab Use Only.

BRPF1 inhibitor NI-42 (NI-42) is a potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM, with excellent selectivity over nonclass IV BRDs.

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25 mg	￥1880	In stock
100 mg	￥4880	In stock
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生物&药学活性

BRPF1 inhibitor NI-42 (NI-42) is a potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM, with excellent selectivity over nonclass IV BRDs.
NI-42 weakly inhibits BRPF2 (BRD1), BRPF3, BRD9 and BRD4 (BD1) with IC50 of 48, 260, 310 and 4500 nM respectively, and no activity for ATAD2A/2B (IC50>100 uM).
NI-42 shows a modest (GI50=1-10 uM) and selective inhibition of proliferation of certain cancer lines, particularly those lines exhibiting monocytic lineage differentiation.
NI-42 is a novel, structurally orthogonal chemical probe for the BRPFs suitable for cellular and in vivo studies.

物理化学性质&存储条件

分子量	353.396
分子式	C18H15N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-benzenesulfonamide

参考文献

1. Igoe N, et al. J Med Chem. 2017 Jan 26;60(2):668-680.

NI-42 (NI42;NI 42;BRPF1 inhibitor NI-42)

生物&药学活性

物理化学性质&存储条件

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NI-42 (NI42;NI 42;BRPF1 inhibitor NI-42)

生物&药学活性

物理化学性质&存储条件

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