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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -NH4-6
NH4-6

Chemical Structure : NH4-6

CAS No.: 2375182-58-2

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NH4-6

货号: PC-72770Not For Human Use, Lab Use Only.

NH4-6 is a potent pan SIRT1-3 inhibitor with IC50 of 3.0/0.032/2.3 uM for SIRT1/2/3, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NH4-6 is a potent, selective pan SIRT1-3 inhibitor with IC50 of 3.0/0.032/2.3 uM for SIRT1/2/3, respectively.
NH4-6 does not inhibits SIRT5 and SIRT6.
NH4-6 (30 mg/kg) significantly impaired tumor growth in HCT-116 tumor xenograft.

物理化学性质&存储条件

分子量 718.824
分子式 C33H59IN4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(2-(((benzyloxy)carbonyl)amino)-6-tetradecanethioamidohexanamido)-N,N,N-trimethylethan-1-aminium iodide

参考文献

1. Jun Young Hong, et al. ACS Chem Biol. 2021 Jul 16;16(7):1266-1275.

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