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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-NH125
NH125

Chemical Structure : NH125

CAS No.: 278603-08-0

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NH125 (NH 125, NH-125)

货号: PC-70179Not For Human Use, Lab Use Only.

NH125 is a potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1280 In stock
25 mg ￥2280 In stock
50 mg ￥3780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NH125 is a potent eukaryotic eEF-2 kinase (eEF2K) inhibitor with IC50 of 60 nM in vitro and blocks the phosphorylation of eEF-2 in intact cells.
NH125 shows relative selectivity over other protein kinases: PKC (IC50=7.5 uM), PKA (IC(50=80 uM), and CaMKII (IC50>100 uM).
NH125 shows efficacious anti-proliferation activityt against different cancer cells.

物理化学性质&存储条件

分子量 524.56
分子式 C27H45IN2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Imidazolium, 1-hexadecyl-2-methyl-3-(phenylmethyl)-, iodide (9CI)

参考文献

1. Yamamoto K, et al. Biosci Biotechnol Biochem. 2000 Apr;64(4):919-23.

2. Arora S, et al. Cancer Res. 2003 Oct 15;63(20):6894-9.

3. Chen Z, et al. J Biol Chem. 2011 Dec 23;286(51):43951-8.

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