NGI-1 derivative C-19 |CAS:924471-88-5 Probechem Biochemicals

Chemical Structure : NGI-1 derivative C-19

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NGI-1 derivative C-19

货号: PC-35568Not For Human Use, Lab Use Only.

NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A.
NGI-1 derivative C-19 reduces ligand stimulated activation of EGFR, in STT3A-ko cells, where EGFR glycosylation is dependent on STT3B alone, does not reduce glycosylation and ligand stimulation of EGFR in parental and STT3B-ko cells.
NGI-1 derivative C-19 has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response (UPR).

物理化学性质&存储条件

分子量	415.508
分子式	C21H25N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(morpholinosulfonyl)-2-(pyrrolidin-1-yl)phenyl)benzamide

参考文献

1. Rinis N, et al. Cell Chem Biol. 2018 Jul 24. pii: S2451-9456(18)30232-0.