NGI-186

Chemical Structure : NGI-186

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货号: PC-24839Not For Human Use, Lab Use Only.

NGI-186 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.06 uM.

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生物&药学活性

NGI-186 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.06 uM.
NGI-186 demonstrates activity against both OST-A and OST-B, with preferential inhibition of OST-A.
NGI-186 induces great accumulation in the G1 phase of the cell cycle in PC-9 cells, causes induction of the pro-apoptotic protein, Bim, and again without an increase in phosphorylation of other RTKs.
NGI-186 inhibits EGFR N-glycosylation, blocks EGFR dependent signaling in EGFR mutant NSCLC.
NGI-186 (10 mg/kg, i.p.) reduces tumor growth in mice bearing MDA-MB-231-ERLucT xenografts.

物理化学性质&存储条件

分子量	464.60
分子式	C21H28N4O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((cyclopropylmethyl)(methyl)amino)-N-(5-ethylthiazol-2-yl)-5-(morpholinosulfonyl)benzamide

参考文献

1. Baro M, et al. Cell Chem Biol. 2025 Jun 19;32(6):839-853.e6.

NGI-186

生物&药学活性

物理化学性质&存储条件

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NGI-186

生物&药学活性

物理化学性质&存储条件

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