NGD-94-1 | D4R inhibitor | Probechem Biochemicals

Chemical Structure : NGD-94-1

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NGD-94-1 (NGD 94-1)

货号: PC-21488Not For Human Use, Lab Use Only.

NGD-94-1 is a highly potent, selective dopamine D4 receptor antagonist with Ki of 3.6 nM.

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生物&药学活性

NGD-94-1 is a highly potent, selective dopamine D4 receptor antagonist with Ki of 3.6 nM.
NGD-94-1 displays 600-fold selectivity for the D4.2 receptor subtype compared with a wide variety of monoamine or other neurotransmitter receptor or modulatory sites except for 5-HT1A and 5-HT3 receptors.
NGD 94-1 completely reverses the decrease in forskolin-stimulated cAMP levels produced by the dopamine receptor full agonist quinpirole.
NGD-94-1 behaves as an agonist in human embryonic kidney 293 cells expressing human recombinant dopamine D4.4 receptors.

物理化学性质&存储条件

分子量	320.40
分子式	C18H20N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-((2-Phenyl-1H-imidazol-5-yl)methyl)piperazin-1-yl)pyrimidine

参考文献

1. Gazi L, et al. Eur J Pharmacol. 1999 May 21;372(3):R9-10.

2. Tallman JF, et al. J Pharmacol Exp Ther. 1997 Aug;282(2):1011-9.

NGD-94-1 (NGD 94-1)

生物&药学活性

物理化学性质&存储条件

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NGD-94-1 (NGD 94-1)

生物&药学活性

物理化学性质&存储条件

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