NG-497 | ATGL inhibitor | Probechem Biochemicals

Chemical Structure : NG-497

CAS No.: 2598242-66-9

加入收藏

NG-497 (NG497)

货号: PC-73184Not For Human Use, Lab Use Only.

NG-497 is a potent, highly selective, nontoxic inhibitor of human adipose triglyceride lipase (ATGL, PNPLA2) with IC50 of 1 uM.

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NG-497 is a potent, highly selective, nontoxic inhibitor of human adipose triglyceride lipase (ATGL, PNPLA2) with IC50 of 1 uM.
NG-497 dose-dependently inhibits TAG hydrolase activity of human ATGL.
NG-497 does not inhibit other TAG hydrolases of the PNPLA family and human acylglycerol hydrolases.
NG-497 also inhibits rhesus monkey ATGL, but has no substantial effects on ATGL orthologues from mouse, rat, goat, pig, dog, and marmoset.
NG-497 dose-dependent decreases isoproterenol-stimulated atty acids (FAs) and glycerol release in human SGBS (IC50=1.5 uM) and primary human adipocytes.
NG-497 reduces lipolysis-dependent respiration of HepG2 cells and does not compromise mitochondrial function via off-target effects.

物理化学性质&存储条件

分子量	315.369
分子式	C18H21NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Methylethyl 6-(4-ethoxyphenyl)-4-methoxy-2-pyridinecarboxylate

参考文献

1. Grabner GF, et al. J Am Chem Soc. 2022 Apr 1. doi: 10.1021/jacs.1c10836.

NG-497 (NG497)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NG-497 (NG497)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.