Chemical Structure : NFS1 inhibitor Compound 53
CAS No.:
54918-93-3
NFS1 inhibitor Compound 53
(PubChem CID 136847320)
货号: PC-24310Not For Human Use, Lab Use Only.
NFS1 inhibitor Compound 53 is the first potent, selective inhibitor of human cysteine desulfurase (NFS1) with IC50 of 40.5 uM and Ki of 6.4 uM.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
NFS1 inhibitor Compound 53 is the first potent, selective inhibitor of human cysteine desulfurase (NFS1) with IC50 of 40.5 uM and Ki of 6.4 uM.
Compound 53 shows no significant inhibitory effects on two other PLP-dependent enzymes, human cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) at 100 uM.
Compound 53 inhibited the proliferation of lung cancer (A549) cells with IC50 of 16.3 uM.
Compound 53 inhibits the activities of ACO and SDH in cells by disrupting Fe-S cluster biosynthesis through the direct inhibition of NFS1 activity, significantly increases the cellular iron content, similar to the effect of the well-recognized ferroptosis inducer, Erastin.
Compound 53 elevates the iron content but does not affect the ROS levels in A549 cells.
Compound 53 synergizes with 2-AAPA to induce ferroptosis.
物理化学性质&存储条件
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分子量
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369.20
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分子式
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C16H14Cl2N2O4
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(2,4-dichlorophenoxy)-N'-(4-hydroxy-3-methoxybenzylidene)acetohydrazide
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参考文献
1. Zhu Z, et al. Int J Mol Sci. 2025 Mar 19;26(6):2782.
