NFEPP | MOR agonist | Probechem Biochemicals

Chemical Structure : NFEPP

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NFEPP (MOR agonist)

货号: PC-35539Not For Human Use, Lab Use Only.

NFEPP is a novel potent, selective pH-dependent μ-opioid receptor (MOR) agonist with a low pKa, shows significantly lower affinity compared with fentanyl at pH 7.4.

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生物&药学活性

NFEPP is a novel potent, selective pH-dependent μ-opioid receptor (MOR) agonist with a low pKa, shows significantly lower affinity compared with fentanyl at pH 7.4.
NFEPP has been shown to produce injury-restricted analgesia in models of inflammatory and postoperative pain, without exhibiting typical opioid side effects.
NFEPP dose-dependently diminished neuropathy-induced mechanical and heat hypersensitivity, and acetic acid-induced abdominal constrictions in vivo.

物理化学性质&存储条件

分子量	354.469
分子式	C22H27FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide

参考文献

1. Rodriguez-Gaztelumendi A, et al. Pain. 2018 Jul 2. doi: 10.1097/j.pain.0000000000001328.

2. Del Vecchio G, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1638-1640.