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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-NF764
NF764

Chemical Structure : NF764

CAS No.:

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NF764 (CTNNB1 degrader NF764)

货号: PC-22501Not For Human Use, Lab Use Only.

NF764 is a potent and selective, covalent β-catenin (CTNNB1) binder and degrader wtih DC50 of 3.5 nM in HT29 cells (Emax=85%), targeting C619 of CTNNB1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NF764 is a potent and selective, covalent β-catenin (CTNNB1) binder and degrader wtih DC50 of 3.5 nM in HT29 cells (Emax=85%), targeting C619 of CTNNB1.
NF764 inhibits CTNNB1 transcriptional activity, demonstrating functional inhibition of the WNT pathway in cells.
NF764 treatment significantly reduced the levels of CTNNB1 target genes,, including MYC, S100A6, AXIN2, and CCND1.
FLAG-CTNNB1 C619S mutation expressing HEK293T cells are completely resistant to NF764-mediated CTNNB1 loss.

物理化学性质&存储条件

分子量 403.40
分子式 C22H20F3NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-1-(2-(5-methoxy-2-(trifluoromethyl)phenyl)pyrrolidin-1-yl)-4-phenylbut-2-ene-1,4-dione

参考文献

1. Gowans FA, et al. J Am Chem Soc. 2024 Jun 6. doi: 10.1021/jacs.4c05174.

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