NF-56-EJ40 | SUCNR1 (GPR91) antagonist | Probechem Biochemicals

Chemical Structure : NF-56-EJ40

CAS No.: 2380230-73-7

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NF-56-EJ40 (SUCNR1 (GPR91) antagonist)

货号: PC-72374Not For Human Use, Lab Use Only.

NF-56-EJ40 is a highly potent, human-selective antagonist of SUCNR1 (GPR91) with IC50 of 25 nM and Ki of 33 nM.

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3880	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NF-56-EJ40 is a highly potent, human-selective antagonist of SUCNR1 (GPR91) with IC50 of 25 nM and Ki of 33 nM.
NF-56-EJ40 is highly selective for human SUCNR1 and showed almost no activity towards rat SUCNR1.
NF-56-EJ40 significantly interrupt succinate/IL-1β signal in HUVECs and macrophages.

物理化学性质&存储条件

分子量	443.54
分子式	C27H29N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(4'-((4-Methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid

参考文献

1. Matthias Haffke, et al. Nature. 2019 Oct;574(7779):581-585.

2. Jingwen Xu, et al. Front Immunol. 2022 Feb 22;13:817572.

NF-56-EJ40 (SUCNR1 (GPR91) antagonist)

生物&药学活性

物理化学性质&存储条件

参考文献

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NF-56-EJ40 (SUCNR1 (GPR91) antagonist)

生物&药学活性

物理化学性质&存储条件

参考文献

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