NERx 329 | RPA inhibitor | Probechem Biochemicals

Chemical Structure : NERx 329

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NERx 329 (RPAi 329, NERx329, NERx-329)

货号: PC-72871Not For Human Use, Lab Use Only.

NERx 329 (RPAi 329, NERx329) is a novel potent, specific inhibitor of replication protein A (RPA), demonstrated potent RPA inhibitory activity in vitro, in vivo, and in cellular assays.

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生物&药学活性

NERx 329 (RPAi 329, NERx329) is a novel potent, specific inhibitor of replication protein A (RPA), demonstrated potent RPA inhibitory activity in vitro, in vivo, and in cellular assays.
NERx 329 (RPAi 329) is specific for inhibiting the RPA ssDNA interaction, does not impact Escherichia coli single strand binding protein (SSB) with ssDNA
NERx 329 (RPAi 329) exhibited single-agent cellular anticancer activity in the H460 NSCLC cell line (IC50=3.5 uM), caused the degradation of replication forks upon stalling and RPA exhaustion.
NERx 329 (RPAi 329) demonstarted in vivo single-agent efficacy in H460 large cell carcinoma and A549 adenocarcinoma xenografts.

物理化学性质&存储条件

分子量	718.033
分子式	C32H37ClIN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-chloro-N-(2-(4-(2-cyanophenyl)-2-methylpiperazin-1-yl)ethyl)-4-fluorobenzenesulfonamide

参考文献

1. Pamela S VanderVere-Carozza, et al. Front Oncol. 2022 Feb 18;12:826655.

NERx 329 (RPAi 329, NERx329, NERx-329)

生物&药学活性

物理化学性质&存储条件

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NERx 329 (RPAi 329, NERx329, NERx-329)

生物&药学活性

物理化学性质&存储条件

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