NEO2734 | CBP/p300-BET inhibitor | Probechem Biochemicals

Chemical Structure : NEO2734

CAS No.: 2081072-29-7

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NEO2734 (NEO-2734, EP31670)

货号: PC-38169Not For Human Use, Lab Use Only.

NEO2734 (NEO-2734, EP31670) is a dual inhibitor of pan-BET and CBP/p300 with Kd values of 2-31 nM.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

NEO2734 (NEO-2734, EP31670) is a dual inhibitor of pan-BET and CBP/p300 with Kd values of 2-31 nM.
NEO2734 exhibited in vitro antitumor activity in a variety of cancer cell lines derived from different tumor types, especially from prostate cancer, leukemias, and lymphomas.
NEO2734 showed a clear in vitro antitumor activity in DLBCL, which was more potent than either a BET inhibitor (birabresib) or a CBP/EP300 inhibitor (SGC-CBP30).
NEO2734 is active in both hotspot mutant (F133V) and non-hotspot mutant (Q165P) PCa cells in vitro and in vivo.

物理化学性质&存储条件

分子量	435.447
分子式	C22H24F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-dimethyl-5-(2-(tetrahydro-2H-pyran-4-yl)-1-(2-(trifluoromethoxy)ethyl)-1H-benzo[d]imidazol-6-yl)pyridin-2(1H)-one

参考文献

1. Yan Y, et al. EMBO Mol Med. 2019 Nov 7;11(11):e10659.

2. Spriano F, et al. Blood Adv. 2020 Sep 8;4(17):4124-4135.

3. Morrison-Smith CD, et al. Mol Cancer Ther. 2020 Jul;19(7):1406-1414.

4. He Y, et al. Nat Commun. 2021 Mar 9;12(1):1521.

NEO2734 (NEO-2734, EP31670)

生物&药学活性

物理化学性质&存储条件

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NEO2734 (NEO-2734, EP31670)

生物&药学活性

物理化学性质&存储条件

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