NEO214 |CAS:1361198-80-2 Probechem Biochemicals

Chemical Structure : NEO214

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NEO214 (NEO-214;NEO 214)

货号: PC-36017Not For Human Use, Lab Use Only.

NEO214 (NEO-214) is a novel, BBB-permeable rolipram-perillyl alcohol conjugate, shows effectivity against both TMZ-sensitive and TMZ-resistant glioma cells (T98G IC50=40 uM).

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生物&药学活性

NEO214 (NEO-214) is a novel, BBB-permeable rolipram-perillyl alcohol conjugate, shows effectivity against both TMZ-sensitive and TMZ-resistant glioma cells (T98G IC50=40 uM).
NEO214 triggers apoptosis by activating the ER stress pathway, induces Death Receptor 5 (DR5) and TNF-related apoptosis inducing ligand (TRAIL/Apo2L) mediated cytotoxicity, without cytotoxicity to normal cells.
NEO214 is generated by covalently conjugating rolipram, a PDE4 (phosphodiesterase 4) inhibitor, to perillyl alcohol, a naturally occurring monoterpene related to limonene.
NEO214 decreases glioma progression in the in vivo mouse tumor model.

物理化学性质&存储条件

分子量	453.579
分子式	C27H35NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((S)-4-(prop-1-en-2-yl)cyclohex-1-en-1-yl)methyl 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate

参考文献

1. Cho HY, et al. Mol Cancer Ther. 2019 Jan 15. pii: molcanther.0465.2018.

NEO214 (NEO-214;NEO 214)

生物&药学活性

物理化学性质&存储条件

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NEO214 (NEO-214;NEO 214)

生物&药学活性

物理化学性质&存储条件

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