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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-NEDD8-NEDD8 inhibitor M22
NEDD8 inhibitor M22

Chemical Structure : NEDD8 inhibitor M22

CAS No.: 864420-54-2

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NEDD8 inhibitor M22

货号: PC-62879Not For Human Use, Lab Use Only.

NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.

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5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg ￥5480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.
M22 inhibit A549 cell proliferation completely at 30 uM (GI50=5.5 uM and GI90=19.3 uM).
M22 produces tumor inhibition in AGS xenografts in nude mice and low acute toxicity in zebrafish model。
M22 exhibts different binding mode compared with MLN4924.

物理化学性质&存储条件

分子量 363.326
分子式 C20H24Cl2N2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-benzyl-N-(2,4-dichlorophenethyl)piperidin-4-amine

参考文献

1. Lu P, et al. ACS Chem Biol. 2016 Jul 15;11(7):1901-7.

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