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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Complement System-NDT9513727
NDT9513727

Chemical Structure : NDT9513727

CAS No.: 439571-48-9

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NDT9513727 (NDT 9513727, NDT-9513727)

货号: PC-61821Not For Human Use, Lab Use Only.

NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay.

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NDT9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay.
NDT 9513727 exhibits potent activity in both gerbil and monkey lung membrane preparations (6.4 and 7.3 nM), but has minimal activity in rat, mouse, and dog lung preparations (>10 uM).
NDT 9513727 blocks hC5a-stimulated chemotaxis activity in human polymorphonuclear neutrophils and U937 cells with IC50 of 4.7 and 4.3 nM, respectively, inhibits C5a-stimulated responses, including guanosine 5'-3-O-(thio)triphosphate binding, Ca(2+) mobilization, oxidative burst, degranulation, cell surface CD11b expression and chemotaxis in various cell types with IC50 of 1.1-9.2 nM.
NDT 9513727 effectively inhibits C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo.

物理化学性质&存储条件

分子量 573.693
分子式 C36H35N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine

参考文献

1. Brodbeck RM, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):898-909.

2. Robertson N, et al. Nature. 2018 Jan 3;553(7686):111-114.

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