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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-NDMC101
NDMC101

Chemical Structure : NDMC101

CAS No.: 1308631-40-4

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NDMC101 (NDMC-101, NDMC 101)

货号: PC-60551Not For Human Use, Lab Use Only.

NDMC101 is a small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NDMC101 is a small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo.
NDMC101 markedly inhibits RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).
NDMC101 significantly reduces the bone-resorbing activity of mature osteoclasts.
NDMC101 reduces arthritic index and mitigated bone erosion in CIA mice.

物理化学性质&存储条件

分子量 265.7
分子式 C13H9ClFNO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide

参考文献

1. Cheng CP, et al. J Clin Immunol. 2012 Aug;32(4):762-77.

2. Liou JT, et al. Eur J Pharmacol. 2014 Mar 5;726:124-32.

3. Lee CC, et al. Eur J Med Chem. 2015 Jun 15;98:115-26.

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