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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MAP4K-NDI-101150
NDI-101150

Chemical Structure : NDI-101150

CAS No.: 2628486-22-4

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NDI-101150 (NDI 101150)

货号: PC-23370Not For Human Use, Lab Use Only.

NDI-101150 is a potent and highly selective hematopoietic progenitor kinase 1 (HPK1, MAP4K1) inhibitor with biochemicals IC50 of 0.7 nM and cellular IC50 of 41 nM.

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5 mg ￥3580 In stock
10 mg ￥5480 In stock
25 mg ￥8980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NDI-101150 is a potent and highly selective hematopoietic progenitor kinase 1 (HPK1, MAP4K1) inhibitor with biochemicals IC50 of 0.7 nM and cellular IC50 of 41 nM.
NDI-101150 displays >400-fold selectivity over closely related MAP4K family members.
NDI-101150 could overcome the immunosuppressive effects of prostaglandin E2, adenosine, and TGF-β on human T cell activation, also directly limits the suppressive capacity of T regulatory cells.
NDI-101150 significantly enhanced the production of antigen-specific antibodies in response to immunization with both T-dependent and T-independent antigens, while anti-PD1 treatment had minimal to no effects on antibody production.
NDI-101150 or anti-PD1 treatments alone induced tumor growth inhibition in the murine CT-26 syngeneic tumor model, NDI-101150 and anti-PD1 in combination mediated complete tumor regressions in several mice.

物理化学性质&存储条件

分子量 486.55
分子式 C27H27FN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-7-((6-((dimethylamino)methyl)-5-(tetrahydrofuran-3-yl)pyridin-2-yl)amino)-4-(7-fluoroimidazo[1,2-a]pyridin-3-yl)isoindolin-1-one

参考文献

1. David Ciccone, et al. Cancer Res (2024) 84 (6_Supplement): 2652.

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