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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-ATP Citrate Lyase (ACL, ACLY) -NDI-091143
NDI-091143

Chemical Structure : NDI-091143

CAS No.: 2375840-87-0

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NDI-091143 (NDI 091143, NDI091143)

货号: PC-36165Not For Human Use, Lab Use Only.

NDI-091143 (NDI091143) is a potent, small-molecule inhibitor of human ATP-citrate lyase (ACLY) with Ki of 7.0 nM and IC50 of 2.1 nM in the ADP-Glo assays.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NDI-091143 (NDI091143) is a potent, small-molecule inhibitor of human ATP-citrate lyase (ACLY, ACL) with Ki of 7.0 nM and IC50 of 2.1 nM in the ADP-Glo assays.
NDI-091143 is located in an allosteric, mostly hydrophobic cavity next to the citrate-binding site, and requires extensive conformational changes in the enzyme that indirectly disrupt citrate binding.

物理化学性质&存储条件

分子量 453.841
分子式 C20H14ClF2NO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate

参考文献

1. Wei J, et al. Nature. 2019 Apr 3. doi: 10.1038/s41586-019-1094-6.

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