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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-NDI-031407
NDI-031407

Chemical Structure : NDI-031407

CAS No.:

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NDI-031407 (NDI 031407)

货号: PC-72038Not For Human Use, Lab Use Only.

NDI-031407 (NDI 031407) is a novel potent, selective TYK2 inhibitor with IC50 of 0.21 nM in radiometric assays, 20 fold selectivity over JAK3 (4.2 nM), 147 fold for JAK2 (31 nM), and 220 fold for JAK1 (46 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NDI-031407 (NDI 031407) is a novel potent, selective TYK2 inhibitor with IC50 of 0.21 nM in radiometric assays, 20 fold selectivity over JAK3 (4.2 nM), 147 fold for JAK2 (31 nM), and 220 fold for JAK1 (46 nM).
NDI-031407 has high potency in cell line and primary cell assays for TYK2-dependent cytokines (IL-12, IC50=118 nM) over TYK2-independent cytokines (GM-CSF).
NDI-031407 blocks IL-23–induced STAT3 phosphorylation and IL-17A production in human CD4+ T cells.
NDI-031407 inhibits disease progression in the SKG model of Spondyloarthritis (SpA).
NDI-031407 suppresses systemic IL-23–induced type 3 immunity in vivo.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

参考文献

1. Eric Gracey, et al. J Clin Invest. 2020 Apr 1;130(4):1863-1878.

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