ND-L11B TFA

Chemical Structure : ND-L11B TFA

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货号: PC-28193Not For Human Use, Lab Use Only.

ND-L11B TFA is an effective degrader of RE-IIBP and NSD2-long, effectively induces NSD2 degradation with DC50 of 1.48 and 0.80 uM in KMS11 MM cell line, reduces H3K36me2 level in cancer cells.

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生物&药学活性

ND-L11B TFA is an effective degrader of RE-IIBP and NSD2-long, effectively induces NSD2 degradation with DC50 of 1.48 and 0.80 uM in KMS11 MM cell line, reduces H3K36me2 level in cancer cells.
ND-L11B treatment downregulated the expression of the NSD2-regulated genes known for their roles in cancer cell proliferation, metastasis and evasion, including: JAM2, MET, PAK1, RRAS2, BACE2, CA2, IGF2BP2, CR2.
ND-L11B exhibited stronger antiproliferative activity on multiple myeloma cell line (KMS11 MM cell, IC50=0.9 uM) and negligible effect on non-malignant normal cell line.

物理化学性质&存储条件

分子量	838.90
分子式	C39H52F6N10O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, 2-[5-[5-[(3S)-3-amino-3-(2,2-difluoroethyl)-1-piperidinyl]-4-[(6-amino-9H-purin-9-yl)methyl]-2-pyridinyl]-2-fluorophenoxy]-N-(11-aminoundecyl)-, 2,2,2-trifluoroacetate (1:1)

参考文献

1. Hu L, et al. Eur J Med Chem. 2024 Dec 17;283:117179.

ND-L11B TFA

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物理化学性质&存储条件

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ND-L11B TFA

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