ND-654 | Acetyl-CoA carboxylase inhibitor | Probechem Biochemicals

Chemical Structure : ND-654

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ND-654 (ND654, ND 654)

货号: PC-36170Not For Human Use, Lab Use Only.

ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively.

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生物&药学活性

ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively.
ND-654 inhibits HepG2 cell fatty acid synthesis with an EC50 of 14 nM, and reduces both rat hepatic malonyl-CoA and rat hepatic fatty acid synthesis with ED50 values of 0.34 mg/kg and 0.30 mg/kg at Cmax, respectively.
ND-654 mimics the effects of ACC phosphorylation inhibits hepatic DNL and the development of HCC.
ND-654 selectively targets the liver and inhibits HCC proliferation, improves survival of tumor-bearing rats when used alone and in combination with the multi-kinase inhibitor sorafenib.

物理化学性质&存储条件

分子量	583.656
分子式	C29H33N3O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-((R)-2-(((1s,4S)-4-hydroxycyclohexyl)oxy)-2-(2-methoxyphenyl)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid

参考文献

1. Lally JSV, et al. Cell Metab. 2019 Jan 8;29(1):174-182.e5.

ND-654 (ND654, ND 654)

生物&药学活性

物理化学性质&存储条件

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ND-654 (ND654, ND 654)

生物&药学活性

物理化学性质&存储条件

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