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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Acetyl-CoA Carboxylase (ACC)-ND-646
ND-646

Chemical Structure : ND-646

CAS No.: 1434639-57-2

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ND-646 (ND646)

货号: PC-20376Not For Human Use, Lab Use Only.

ND-646 (ND646) is a potent, selective and allosteric inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of 3.5 and 4.2 nM for hACC1 and hACC2, respectively.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ND-646 (ND646) is a potent, selective and allosteric inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of 3.5 and 4.2 nM for hACC1 and hACC2, respectively.
ND-646 interacts within the dimerization site of the BC domain of ACC, specifically binds to Arg172 in human ACC1 (hACC1R172) and Arg277 in human ACC2 (hACC2R277).
ND-646 treatment led to a complete loss of P-ACC detection in A549 cells without affecting total ACC protein levels.
ND-646 inhibits fatty acid synthesis (FASyn) in vitro, depletes cellular levels of fatty acids and induces apoptosis in NSCLC cells.
ND-646 (25 mg/kg QD) inhibits tumor growth in A549 NSCLC xenograft models.
ND-646 inhibits FASyn in lung tumors of KrasG12D p53−/− and KrasG12D Lkb1−/− mouse models of NSCLC and lowers plasma free fatty acids.
ND-646 suppresses KrasG12D p53−/− and KrasG12D Lkb1−/− autochthonous NSCLC tumor growth.

物理化学性质&存储条件

分子量 568.65
分子式 C28H32N4O7S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanamide

参考文献

1. Svensson RU, et al. Nat Med. 2016 Oct;22(10):1108-1119.

2. Li EQ, et al. Eur J Pharm Sci. 2019 Sep 1;137:105010.

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