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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-ND-378
ND-378

Chemical Structure : ND-378

CAS No.: 1807453-72-0

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ND-378 (ND378;ND 378)

货号: PC-60174Not For Human Use, Lab Use Only.

ND-378 (ND378) is a potent, selective MMP-2 inhibitor with Ki of 230 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ND-378 (ND378) is a potent, selective MMP-2 inhibitor with Ki of 230 nM.
    ND-378 does not inhibit the closely related MMP-9 or MMP-14, and other MMPs (Ki>50 uM).
    ND-378 can cross the blood-spinal cord barrier, achieving therapeutic concentrations in the injured spinal cord, shows no change in long-term neurological outcomes in mice.

    物理化学性质&存储条件

    分子量 377.473
    分子式 C18H19NO4S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)benzyl)acetamide

    参考文献

    1. Gao M, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487.

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