欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-ND-011992
ND-011992

Chemical Structure : ND-011992

CAS No.: 2446880-46-0

加入收藏

ND-011992 (ND011992)

货号: PC-20990Not For Human Use, Lab Use Only.

ND-011992 is a cytochrome bd oxidase (Cyt-bd) inhibitor, inhibits Mycobacterium tuberculosis respiratory complex I with IC50 of 0.12 uM, targets respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥3280 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ND-011992 is a cytochrome bd oxidase (Cyt-bd) inhibitor, inhibits Mycobacterium tuberculosis respiratory complex I with IC50 of 0.12 uM, targets respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases.
ND-011992 is active against M. tuberculosis H37Rv with IC50 of 2.8-4.2 μM.
ND-011992 synergizes with Q203 to inhibit ATP production and growth in mycobacteria.
ND-011992 lowers the minimum inhibitory concentration 50% (MIC50) of Q203 (Cat. PC-42302) from 3.16 to 0.97 nM in M. tuberculosis H37Rv.
ND-011992 inhibits oxygen consumption in the presence of Q203.
ND-011992 inhibits M. bovis BCG oxygen consumption rate (OCR) with IC50 of 0.8 uM.
ND-011992 does not affect electron transfer within the cytochrome bcc:aa3 supercomplex.
ND-011992 has a low spontaneous resistance mutation frequency and is active against drug‐resistant M. tuberculosis clinical isolates.
The combination ND-011992/Q203 is bactericidal against replicating and non‐replicating M. tuberculosis H37Rv and shows potency in vivo.
ND-011992 acts on both, quinone reductases and quinol oxidases and could be very well suited to regulate the activity of the entire respiratory chain.

物理化学性质&存储条件

分子量 381.36
分子式 C21H14F3N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(4-(trifluoromethyl)phenoxy)phenyl)quinazolin-4-amine

参考文献

1. Lee BS, et al. EMBO Mol Med. 2021 Jan 11;13(1):e13207.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: