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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-ND-011992
ND-011992

Chemical Structure : ND-011992

CAS No.: 2446880-46-0

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ND-011992 (ND011992)

货号: PC-20990Not For Human Use, Lab Use Only.

ND-011992 is a cytochrome bd oxidase (Cyt‐bd) inhibitor, inhibits Mycobacterium tuberculosis respiratory complex I with IC50 of 0.12 uM, targets respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ND-011992 is a cytochrome bd oxidase (Cyt‐bd) inhibitor, inhibits Mycobacterium tuberculosis respiratory complex I with IC50 of 0.12 uM, targets respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases.
ND-011992 is active against M. tuberculosis H37Rv with IC50 of 2.8-4.2 μM.
ND‐011992 synergizes with Q203 to inhibit ATP production and growth in mycobacteria.
ND‐011992 lowers the minimum inhibitory concentration 50% (MIC50) of Q203 (Cat. PC-42302) from 3.16 to 0.97 nM in M. tuberculosis H37Rv.
ND‐011992 inhibits oxygen consumption in the presence of Q203.
ND‐011992 inhibits M. bovis BCG oxygen consumption rate (OCR) with IC50 of 0.8 uM.
ND‐011992 does not affect electron transfer within the cytochrome bcc:aa3 supercomplex.
ND‐011992 has a low spontaneous resistance mutation frequency and is active against drug‐resistant M. tuberculosis clinical isolates.
The combination ND‐011992/Q203 is bactericidal against replicating and non‐replicating M. tuberculosis H37Rv and shows potency in vivo.
ND-011992 acts on both, quinone reductases and quinol oxidases and could be very well suited to regulate the activity of the entire respiratory chain.

物理化学性质&存储条件

分子量 381.36
分子式 C21H14F3N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

FC(C1=CC=C(OC2=CC=C(NC3=C4C=CC=CC4=NC=N3)C=C2)C=C1)(F)F

参考文献

1. Lee BS, et al. EMBO Mol Med. 2021 Jan 11;13(1):e13207.

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