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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-NCT02
NCT02

Chemical Structure : NCT02

CAS No.: 790245-61-3

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NCT02 (CCNK-CDK12 degrader NCT02)

货号: PC-73186Not For Human Use, Lab Use Only.

NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.

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10 mg ￥1280 In stock
25 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.
NCT02 decreases proliferation of CRC cells in vitro and tumor growth in vivo.
Pharmacological CCNK/CDK12 degradation via NCT02 is associated with TP53 deficiency and consensus molecular subtype 4 in vitro and in patient-derived xenografts.

物理化学性质&存储条件

分子量 312.387
分子式 C17H16N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)-

参考文献

1. Sebastian M Dieter, et al. Cell Rep. 2021 Jul 20;36(3):109394.

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