NCT02 | CCNK-CDK12 degrader | Probechem Biochemicals

Chemical Structure : NCT02

CAS No.: 790245-61-3

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NCT02 (CCNK-CDK12 degrader NCT02)

货号: PC-73186Not For Human Use, Lab Use Only.

NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.

规格	价格	库存
5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.
NCT02 decreases proliferation of CRC cells in vitro and tumor growth in vivo.
Pharmacological CCNK/CDK12 degradation via NCT02 is associated with TP53 deficiency and consensus molecular subtype 4 in vitro and in patient-derived xenografts.

物理化学性质&存储条件

分子量	312.387
分子式	C17H16N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)-

参考文献

1. Sebastian M Dieter, et al. Cell Rep. 2021 Jul 20;36(3):109394.

NCT02 (CCNK-CDK12 degrader NCT02)

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物理化学性质&存储条件

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NCT02 (CCNK-CDK12 degrader NCT02)

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物理化学性质&存储条件

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