NCT-507 |CAS: 2231081-18-6 Probechem Biochemicals

Chemical Structure : NCT-507

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NCT-507 (NCT507)

货号: PC-35128Not For Human Use, Lab Use Only.

NCT-507 (NCT507) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

NCT-507 (NCT507) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.
NCT-507 also exhibits IC50 of 53 nM in MIA PaCa-2 Aldefluor cell-based assays.
NCT-507 demonstrates target engagement in CETSA asssays, inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.

物理化学性质&存储条件

分子量	494.994
分子式	C25H23ClN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(6-chloro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)phenyl)cyclopropane-1-carbonitrile

参考文献

1. Yang SM, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00270.

NCT-507 (NCT507)

生物&药学活性

物理化学性质&存储条件

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NCT-507 (NCT507)

生物&药学活性

物理化学性质&存储条件

参考文献

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