NCT-505 |CAS:2231079-75-5 Probechem Biochemicals

Chemical Structure : NCT-505

CAS No.: 2231079-75-5

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NCT-505 (NCT505, NCT 505)

货号: PC-35126Not For Human Use, Lab Use Only.

NCT-505 (NCT505) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.

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5 mg	￥3980	In stock
10 mg	￥5880	In stock
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生物&药学活性

NCT-505 (NCT505) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.
NCT-505 also exhibits IC50 of 30 nM in MIA PaCa-2 Aldefluor cell-based assays.
NCT-505 demonstrates target engagement in CETSA asssay (EC50=3.4 uM), inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.

物理化学性质&存储条件

分子量	635.635
分子式	C29H29F4N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(6-Fluoro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)-4-phenylpiperidine-4-carbonitrile, TFA

参考文献

1. Yang SM, et al. J Med Chem. 2018 Jun 14;61(11):4883-4903.

NCT-505 (NCT505, NCT 505)

生物&药学活性

物理化学性质&存储条件

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NCT-505 (NCT505, NCT 505)

生物&药学活性

物理化学性质&存储条件

参考文献

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