NCOA4-FTH1 inhibitor 9a

Chemical Structure : NCOA4-FTH1 inhibitor 9a

CAS No.: 2650557-72-3

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货号: PC-22833Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥2880	In stock
10 mg	￥4480	In stock
25 mg	￥7580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NCOA4-FTH1 inhibitor 9a is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells.
NCOA4-FTH1 inhibitor 9a directly binds to recombinant protein NCOA4383–522 (Kd=7.48 uM) and effectively blocks the NCOA4383–522–FTH1 interaction.
NCOA4-FTH1 inhibitor 9a significantly ameliorates the ischemic-refusion injury in rat model of ischemic stroke.
NCOA4-FTH1 inhibitor 9a is a selective ferroptosis inhibitor that effectively suppresses lipid peroxidation and rescues cells from ferroptosis.
NCOA4-FTH1 inhibitor 9a inhibits lysosomal ferritin degradation and localizes in autophagosomes. effectively blocks RSL3-induced ferroptosis in HT22 cells (EC50 = 3.66 μM).

物理化学性质&存储条件

分子量	441.55
分子式	C27H28FN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Fluoro-1,2,3,4-tetrahydro-2-[3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]phenyl]isoquinoline

参考文献

1. Fang Y, et al. ACS Cent Sci. 2021 Jun 23;7(6):980-989.