NCGC607 | GCase activator | Probechem Biochemicals

Chemical Structure : NCGC607

CAS No.: 1462267-07-7

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NCGC607 (NCGC00241607)

货号: PC-38530Not For Human Use, Lab Use Only.

NCGC00241607 (NCGC607) is a small-molecule noninhibitory chaperone of glucocerebrosidase (GCase), successfully chaperoned the mutant enzyme, restored GCase activity and protein levels, and reduced glycolipid storage in neurons.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

NCGC00241607 (NCGC607) is a small-molecule noninhibitory chaperone of glucocerebrosidase (GCase), successfully chaperoned the mutant enzyme, restored GCase activity and protein levels, and reduced glycolipid storage in neurons.
NCGC607 (3 uM) significantly enhanced GCase activity and increased GCase levels in Gaucher macrophages.
Treatment of Gaucher iDA neurons with NCGC607 increased GCase activity, enhanced translocation of mutant GCase to the lysosome, and reduced substrate levels.
NCGC607 (3 uM) reversed α-Syn accumulation in GD-PD iDA neurons.

物理化学性质&存储条件

分子量	543.3
分子式	C24H22IN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-[(4-iodophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]-benzamide

参考文献

1. Elma Aflaki, et al. J Neurosci. 2016 Jul 13;36(28):7441-52.

NCGC607 (NCGC00241607)

生物&药学活性

物理化学性质&存储条件

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NCGC607 (NCGC00241607)

生物&药学活性

物理化学性质&存储条件

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