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首页-小分子抑制剂&激动剂-Others-Other Targets-NCGC00685960
NCGC00685960

Chemical Structure : NCGC00685960

CAS No.: 3091000-99-3

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NCGC00685960

货号: PC-26936Not For Human Use, Lab Use Only.

NCGC00685960 is a highly potent, specific Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 of <10 nM, increases H3K27 trimethylation levels in ovarian cancer cells and inhibits α-SMA expression in NNMT-expressing ovarian fibroblasts, has potent antitumor activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NCGC00685960 is a highly potent, specific Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 of <10 nM, increases H3K27 trimethylation levels in ovarian cancer cells and inhibits α-SMA expression in NNMT-expressing ovarian fibroblasts, has potent antitumor activity.

物理化学性质&存储条件

分子量 458.00
分子式 C24H32ClN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-8-(3-(1-(2-Cyclohexylethyl)piperidin-3-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)quinolin-2(1H)-one hydrochloride

参考文献

1. Heide J, et al. NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity. Nature. 2025;645(8082):1051-1059.

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