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首页-小分子抑制剂&激动剂-Others-Other Targets-NCGC00378430
NCGC00378430

Chemical Structure : NCGC00378430

CAS No.: 920650-00-6

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NCGC00378430 (Compound 8430)

货号: PC-72451Not For Human Use, Lab Use Only.

NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg ￥5880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay.
NCGC00378430 partially reversed transcriptional and metabolic profiles mediated by SIX1 overexpression and reversed SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT), also reverses SIX1-induced TGF-β signaling and EMT in vitro in breast cancer cells.
NCGC00378430 had little toxicity in vivo.
NCGC00378430 disrupts the SIX1-EYA2 interaction and transcriptional activity, partially reverses SIX1-mediated transcriptional and metabolic signatures in breast tumor cells.
NCGC00378430 inhibits TGF-β signaling and EMT in breast cancer cells with high SIX1 expression.
NCGC00378430 inhibits metastasis of breast cancer cells expressing high levels of SIX1 in vivo.

物理化学性质&存储条件

分子量 441.502
分子式 C22H23N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Methoxy-3-(morpholinosulfonyl)phenyl)-3-(1H-pyrrol-1-yl)benzamide

参考文献

1. Hengbo Zhou, et al. Cancer Res. 2020 Jun 15;80(12):2689-2702.

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