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首页-小分子抑制剂&激动剂-Others-Other Targets-NCGC00238624
NCGC00238624

Chemical Structure : NCGC00238624

CAS No.: 2768230-55-1

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NCGC00238624

货号: PC-26468Not For Human Use, Lab Use Only.

NCGC00238624 is a highly selective galactokinase (GALK1) inhibitor with IC50 of 7.69 and 13.67 uM against the human and mouse recombinant GALK1, respectively, lowers gal-1P levels in primary fibroblast cells derived from patients with classic galactosemia.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NCGC00238624 is a highly selective galactokinase (GALK1) inhibitor with IC50 of 7.69 and 13.67 uM against the human and mouse recombinant GALK1, respectively, lowers gal-1P levels in primary fibroblast cells derived from patients with classic galactosemia.

物理化学性质&存储条件

分子量 382.81
分子式 C18H15ClN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5(1H)-Quinazolinone, 2-(2-benzoxazolylamino)-4-(4-chloro-1H-pyrazol-3-yl)-4,6,7,8-tetrahydro-, (4R)-

参考文献

1. Li Liu, et al. J Med Chem. 2021 Sep 23;64(18):13551-13571.

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