NCGC00135472 | DRV1/GPR32 agonist | Probechem Biochemicals

Chemical Structure : NCGC00135472

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NCGC00135472 (DRV1 (GPR32) agonist C2A)

货号: PC-35891Not For Human Use, Lab Use Only.

DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively.

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生物&药学活性

DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively.
DRV1 (GPR32) agonist C2A (NCGC00135472) elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages.
DRV1 (GPR32) agonist C2A (NCGC00135472) also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli.

物理化学性质&存储条件

分子量	364.356
分子式	C20H14F2N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide

参考文献

1. Chiang N, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30383-0.

NCGC00135472 (DRV1 (GPR32) agonist C2A)

生物&药学活性

物理化学性质&存储条件

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NCGC00135472 (DRV1 (GPR32) agonist C2A)

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物理化学性质&存储条件

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