NCGC00092410

Chemical Structure : NCGC00092410

CAS No.: 442898-34-2

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货号: PC-26939Not For Human Use, Lab Use Only.

NCGC00092410 is a potent, selective and nonsugar glucocerebrosidase (GC, GCase) inhibitor with IC50 of 31 nM.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

NCGC00092410 is a potent, selective and nonsugar glucocerebrosidase (GC, GCase) inhibitor with IC50 of 31 nM.
shows no activity against the related hydrolases (α-glucosidase (α-Gluc), α-galactosidase (α-Gal), and β-N-acetylglucosaminidase (HEX)) at concentrations up to 77 uM.
also increases GC activity in cells demonstrates their potential as GC chaperones, indueces increasing the activity and lysosomal localization of glucocerebrosidase in mutant cell lines.

物理化学性质&存储条件

分子量	353.47
分子式	C21H27N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Methyl-2-morpholinoquinolin-6-yl)cyclohexanecarboxamide

参考文献

1. Zheng W, et, al. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7.

NCGC00092410

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NCGC00092410

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