NCGC00071837 |CAS:578747-98-5 Probechem Biochemicals

Chemical Structure : NCGC00071837

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NCGC00071837 (PDE4-IN-5A)

货号: PC-62068Not For Human Use, Lab Use Only.

NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.

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1 g		Get quote

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生物&药学活性

NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.
NCGC00071837 directly stimulates (in the absence of NKH 477) and potentiates (in the presence of NKH 477) cAMP production.

物理化学性质&存储条件

分子量	382.438
分子式	C19H18N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(3,4-dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

参考文献

1. Xia M, et al. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7.

2. Skoumbourdis AP, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1297-303.

NCGC00071837 (PDE4-IN-5A)

生物&药学活性

物理化学性质&存储条件

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NCGC00071837 (PDE4-IN-5A)

生物&药学活性

物理化学性质&存储条件

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