NCATS-SM7270

Chemical Structure : NCATS-SM7270

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货号: PC-49686Not For Human Use, Lab Use Only.

NCATS-SM7270 is a specific small molecule NADPH oxidase 2 (NOX2) inhibitor with IC50 of 2.1 uM (Polymorphonuclear leukocytes, PMN), inhibits NOX2 in primary human and mouse granulocytes.

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生物&药学活性

NCATS-SM7270 is a specific small molecule NADPH oxidase 2 (NOX2) inhibitor with IC50 of 2.1 uM (Polymorphonuclear leukocytes, PMN), inhibits NOX2 in primary human and mouse granulocytes.
NCATS-SM7270 exhibited improved permeability, solubility, and half-life in rat microsomes, which retained similar activity against human neutrophil NOX2 and lower activity against xanthine oxidase compared to GSK2795039.
NCATS-SM7270 displayed no detectable activity against NOX3 and NOX4, and only marginal activity at the highest dose tested (about 100x the IC50 versus NOX2) against NOX1 and NOX5.
NCATS-SM7270 specifically inhibited NOX2 and had reduced inhibitory activity against xanthine oxidase in vitro.
NCATS-SM7270 protected mice from mild traumatic brain injury, partially reversed mild traumatic brain injury (mTBI) in NOX4KO mice.

物理化学性质&存储条件

分子量	446.53
分子式	C23H22N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-cyclopropyl-3-(1-methyl-1H-indol-6-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

参考文献

1. Hannah Mason, et al. Redox Biol. 2023 Jan 18;60:102611.

NCATS-SM7270

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物理化学性质&存储条件

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NCATS-SM7270

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物理化学性质&存储条件

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