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首页-小分子抑制剂&激动剂-Others-Other Targets-NCATS-SM4487
NCATS-SM4487

Chemical Structure : NCATS-SM4487

CAS No.: 2733617-81-5

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NCATS-SM4487 (NCATS-SM 4487)

货号: PC-72398Not For Human Use, Lab Use Only.

NCATS-SM4487 is a potent, small molecule inhibitor galactokinase (GALK1) with IC50 of 50 nM (hGALK1).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NCATS-SM4487 is a potent, small molecule inhibitor galactokinase (GALK1) with IC50 of 50 nM (hGALK1).
    NCATS-SM4487 prevents galactose-1 phosphate (gal-1P) accumulation in patient-derived cells at low micromolar concentrations and have pharmacokinetic properties suitable for evaluation in rodent models of galactosemia.

    物理化学性质&存储条件

    分子量 522.969
    分子式 C25H24ClFN8O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((7-amino-6-fluorobenzo[d]oxazol-2-yl)amino)-4-(2-chloro-4-methylphenyl)-6-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1,4-dihydropyrimidine-5-carboxamide

    参考文献

    1. Li Liu, et al. J Med Chem. 2021 Sep 23;64(18):13551-13571.

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