NCATS-SM0708

Chemical Structure : NCATS-SM0708

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货号: PC-26953Not For Human Use, Lab Use Only.

NCATS-SM0708 is a potent, selective Aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor with biochemical IC50 of 13.62 nM in enzymatic assays, and cellular IC50 of 3.84 nM in ALDEFLUOR assays.

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生物&药学活性

NCATS-SM0708 is a potent, selective Aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor with biochemical IC50 of 13.62 nM in enzymatic assays, and cellular IC50 of 3.84 nM in ALDEFLUOR assays.
NCATS-SM0708 demonstrates weak to inactive activity against ALDH1A1, ALDH1A2, ALDH2, and ALDH3A2, exhibiting moderate activity against ALDH1A3 (IC50 = 1.12 uM).

物理化学性质&存储条件

分子量	543.63
分子式	C26H24F3N5OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(2-methylthiazol-4-yl)benzyl)-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)thiazole-4-carboxamide

参考文献

1. Sankalp Jain, et al. J Med Chem. 2026 May 30. doi: 10.1021/acs.jmedchem.6c00537.

NCATS-SM0708

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物理化学性质&存储条件

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NCATS-SM0708

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物理化学性质&存储条件

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