NCA029

Chemical Structure : NCA029

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货号: PC-23500Not For Human Use, Lab Use Only.

NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with EC50 of 0.2 uM.

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生物&药学活性

NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with EC50 of 0.2 uM.
NCA029 targeted HsClpP, inducing mitochondrial dysfunction and activating the ATF3-dependent integrated stress response, ultimately causing cell death in colorectal adenocarcinoma.
NCA029 displayed favorable pharmacokinetics and safety profiles and significantly inhibited tumor growth in HCT116 xenografts, resulting in 83.6% tumor inhibition.

物理化学性质&存储条件

分子量	399.42
分子式	C22H20F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-cyanobenzyl)-N-(4-(trifluoromethyl)benzyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

参考文献

1. Jiangnan Zhang, et al. J Med Chem. 2024 Feb 22;67(4):2812-2836.

NCA029

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NCA029

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