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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-NC-001
NC-001

Chemical Structure : NC-001

CAS No.: 1237540-68-9

NC-001 (NC001, az-NC-001)

货号: PC-60969Not For Human Use, Lab Use Only.

NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1), does not correlate with inhibition of chymotrypsin-like sites.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1), does not correlate with inhibition of chymotrypsin-like sites.

    物理化学性质&存储条件

    分子量 535.646
    分子式 C25H41N7O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-1-((2-azidoacetyl)-L-alanyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxohexan-2-yl)pyrrolidine-2-carboxamide

    参考文献

    1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89.

    2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

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