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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-NBQX
NBQX

Chemical Structure : NBQX

CAS No.: 118876-58-7

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NBQX (FG9202, FG-9202)

货号: PC-61719Not For Human Use, Lab Use Only.

NBQX is a potent, selective and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.15 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NBQX is a potent, selective and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.15 uM.
NBQX binds to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites.
NBQX also blocks kainate receptor with IC50 of 4.8 uM.
NBQX exhibits anticonvulsant activity in rodent seizure models.

物理化学性质&存储条件

分子量 336.28
分子式 C12H8N4O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide

参考文献

1. Sheardown MJ, et al. Science. 1990 Feb 2;247(4942):571-4.

2. Klockgether T, et al. Ann Neurol. 1991 Nov;30(5):717-23.

3. Gill R, et al. Brain Res. 1992 May 15;580(1-2):35-43.

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