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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-NBD-14273
NBD-14273

Chemical Structure : NBD-14273

CAS No.: 3032325-35-9

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NBD-14273 (NBD 14273)

货号: PC-73246Not For Human Use, Lab Use Only.

NBD-14273 is a CD4-mimetic, small-molecule HIV-1 entry inhibitor with IC50 of 0.13 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NBD-14273 is a CD4-mimetic, small-molecule HIV-1 entry inhibitor with IC50 of 0.13 uM.
    NBD-14273 showed both improved antiviral activity and selectivity index (SI) against HIV-1HXB2 compared to NBD-14136.
    NBD-14273 displayed potenct against a large panel of 50 HIV-1 Env-pseudotyped viruses representing clinical isolates of diverse subtypes.

    物理化学性质&存储条件

    分子量 442.433
    分子式 C19H18F4N4O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1H-Pyrrole-2-carboxamide, N-[(1S)-2-amino-1-[4-(2-hydroxyethyl)-2-thiazolyl]ethyl]-5-[2-fluoro-4-(trifluoromethyl)phenyl]-

    参考文献

    1. Francesca Curreli, et al. Bioorg Med Chem. 2021 Feb 15;32:116000.

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